Developing More Predictive In Vitro Models
3rd Annual Summit
Cutting Edge Advancements in In Vitro Models to Mitigate Toxicity, Streamline Drug Development and Direct Clinical Strategy
25 – 27 September 2012 | Boston
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Guoying Tai
Guoying Tai obtained a PhD in Medicinal Chemistry from the University of Washington, Seattle, under guidance of Dr. Allen Rettie. Her thesis research focused on the structure-function relationships of P450 enzymes (CYP2Cs) and CYP2C9 pharmacogenetics, in vitro and in vivo.
After joining the DMPK Department at GlaxoSmithKline in 2006, her research interest has centered around drug-drug interaction risk assessment through IVIVE via static models and Simcyp simulations.
Guoying’s current effort is on developing and using physiologically-based pharmacokinetic models for prediction and simulation of CYP induction to enhance mechanistic understanding for NCEs during various stages of drug development.