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Speaker Interview: Dr Evangelos Kiskinis, Postdoctoral Fellow, Kevin Eggan Lab, Howard Hughes Medical Institute, Harvard University

Interview with Dr Evangelos Kiskinis, speaking on his thoughts regarding induced pluripotent stem (iPS) cells, ALS and bridging the gap between academic research and drug development. 

Presentation: Elena S. Trepakova "Assessing Predictive Value of Integrated Analysis of In Vitro Ion Channel Assays for Adverse Cardiovascular Effects in In Vivo Models"

Elena S. Trepakova, Research Fellow, Department of Toxicological Sciences, Merck 

41 Page slide presentation from Predictive In Vitro Models covering topics including need to predict clinical outcome better by improving preclinical models and quality of data, need to identify CV adverse drug effects as early in development as possible and automated Voltage Clamp - early in-vitro screening technology (fast, cheap, higher throughput)

Paper: Studying The Effect of Acetylcholine in Reducing Excitability Of A-V Junctional Fibers And Slowing The Cardiac Impulse Into The Ventricles. A Synthetic Neurotransmitter’s ( Acetylcholine Chloride) in-vitro Oxidation

Authors:  Dr. Waseem Mahmud Kayani Western Illinois University, Dr. Nekatal Made Gowda Western Illinois University.

Major effect of acetylcholine on heart function is to regulate its function by decreasing the heart rate. We studied the break down of acetylcholine chloride by chloramine-T  and it was spectrophotometrically monitored at λ_max of 256 nm. The dependencies of the reaction rate on acetylcholine chloride and the reduction product of CAT, p-toluenesulfonamide, were studied. A mechanism consistent with the observed kinetic data has been proposed and discussed.

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